• Associations with antibiotic prescribing for acute exacerbation of COPD in primary care: Secondary analysis of a randomised controlled trial 

      Gillespie, David; Butler, Christopher C.; Bates, Janine; Hood, Kerenza; Melbye, Hasse; Phillips, Rhiannon; Stanton, Helen; Alam, Mohammed Fasihul; Cals, Jochen; Cochrane, Ann; Kirby, Nigel; Llor, Carl; Lowe, Rachel; Naik, Gurudutt; Riga, Evgenia; Sewell, Bernadette; Thomas-Jones, Emma; White, Patrick; Francis, Nick (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-03-26)
      <i>Background</i> - C-reactive protein (CRP) point-of-care testing can reduce antibiotic use in patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD) in primary care, without compromising patient care. Further safe reductions may be possible.<br><br> <i>Aim</i> - To investigate the associations between presenting features and antibiotic prescribing in patients with ...
    • Associations with Post-Consultation Health-Status in Primary Care Managed Acute Exacerbation of COPD 

      Gillespie, David; Francis, Nick; Ahmed, Haroon; Hood, Kerenza; Llor, Carl; White, Patrick; Thomas-Jones, Emma; Stanton, Helen; Sewell, Bernadette; Phillips, Rhiannon; Naik, Gurudutt; Melbye, Hasse; Lowe, Rachel; Kirby, Nigel; Cochrane, Ann; Bates, Janine; Alam, Mohammed Fasihul; Butler, Christopher (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-02-16)
      Background: It has been demonstrated that antibiotic prescribing for Acute Exacerbations of Chronic Obstructive Pulmonary Disease (AECOPD) can be safely reduced in primary care when general practitioners have access to C-reactive protein (CRP) rapid testing.<p> <p>Aim: To investigate the factors associated with post-consultation COPD health status in patients presenting with AECOPD in this sett ...
    • C-reactive protein point-of-care testing for safely reducing antibiotics for acute exacerbations of chronic obstructive pulmonary disease: The PACE RCT 

      Francis, Nick; Gillespie, David; White, Patrick; Bates, Janine; Lowe, Rachel; Sewell, Bernadette; Phillips, Rhiannon; Stanton, Helen; Kirby, Nigel; Wootton, Mandy; Thomas-Jones, Emma; Hood, Kerenza; Llor, Carl; Cals, Jochen; Melbye, Hasse; Naik, Gurudutt; Gal, Micaela; Fitzsimmons, DF; Alam, Mohammed Fasihul; Riga, Evgenia; Cochrane, Ann; Butler, Christopher C. (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-03)
      Background - Most patients presenting with acute exacerbations of chronic obstructive pulmonary disease (AECOPD) in primary care are prescribed antibiotics, but these may not be beneficial, and they can cause side effects and increase the risk of subsequent resistant infections. Point-of-care tests (POCTs) could safely reduce inappropriate antibiotic prescribing and antimicrobial resistance.<p> ...
    • C-reactive protein-guided antibiotic prescribing for COPD exacerbations: A qualitative evaluation 

      Phillips, Rhiannon; Stanton, H.; Singh-Mehta, A.; Gillespie, David; Bates, Janine; Gal, Micaela; Thomas-Jones, Emma; Lowe, Rachel; Hood, Kerenza; Llor, Carl; Melbye, Hasse; Cals, Jochen; White, Patrick; Butler, Christopher C.; Francis, Nick (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-06-25)
      Background - Antibiotics are prescribed to >70% of patients presenting in primary care with an acute exacerbation of chronic obstructive pulmonary disease (AECOPD). The PACE randomised controlled trial found that a C-reactive protein point-of-care test (CRP-POCT) management strategy for AECOPD in primary care resulted in a 20% reduction in patient-reported antibiotic consumption over 4 weeks.<p> <p>Aim ...